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POF joining hinges on active transcription.

You will find previously shown one POF attach to help you energetic genes into the 4th chromosome having a preference to have exons and therefore the fresh new levels of POF binding to help you family genes associate with transcript accounts (27). We ergo wanted to determine whether there was a love ranging from the fresh new joining from POF which regarding RNA polymerase II (RNP2). To deal with so it concern, we heat astonished Drosophila larvae for 45 min at the 38°C and tracked the fresh reassociation out of POF and you will RNP2 so you’re able to chromatin. Since is the actual situation that have RNP2, POF was also put-out from its typical chromatin target sites once the heat treat, nonetheless it wasn’t redistributed in order to heat shock-caused family genes. One another POF plus the RNP2 was basically recovered to their normal withdrawals toward chromosomes during a period of approximately dos h ( Fig. 1 ). The brand new temporary pages of discharge as well as the after that recuperation away from POF and you may RNP2 joining shortly after temperatures amaze was in fact comparable, recommending that there’s a love between the joining of the you to definitely and that of one’s almost every other.

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